Clinical Trial

A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis

Study acronym: ADAPT oculus
Active, Not Recruiting Phase 3
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Summary
The purpose of this study is to evaluate the efficacy and safety of efgartigimod PH20 SC given by a pre-filled syringe in adult patients with ocular myasthenia gravis. The study consists of a part A (approximately 7 weeks) and a part B (up to 2 years). In part A, half of the participants will receive efgartigimod PH20 SC and the other half will receive placebo. In part B, all participants will receive efgartigimod PH20 SC. The participants will be in the study for about up to 2 years and 12 weeks.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2024-08-14; most recent amendment 2026-07-01.
Status change: Recruiting → Active, Not Recruiting 2025-12-10
Status change: Not Yet Recruiting → Recruiting 2024-10-08
Trial Details
NCT Number NCT06558279
Lead Sponsor argenx
Conditions Myasthenia Gravis, Ocular
Enrollment 141 participants
Start Date 2024-09-18
Primary Completion 2026-01-12 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-07-02