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NCT06548100 · ClinicalTrials.gov record · last posted 2026-07-29

A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)

StatusCompleted
PhasePhase 3
Started2024-12-16
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from the ClinicalTrials.gov record
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months. The aim of the study is to see how safe and tolerable mibavademab is when switching from treatment with metreleptin. The study is looking at several other research questions, including: * What side effects may happen from taking mibavademab * How much mibavademab is in the blood at different times * Whether the body makes antibodies against mibavademab (which could make mibavademab less effective or could lead to side effects)

Protocol amendment history 2 changes detected by DataLookout

2026-07-30
notable
Trial completed
2026-07-30
minor
Completion moved earlier: 2026-11-03 → 2026-07-09
Trial Details
NCT Number NCT06548100
Lead Sponsor Regeneron Pharmaceuticals
Conditions Generalized Lipodystrophy
Enrollment 9 participants
Start Date 2024-12-16
Primary Completion 2026-07-09 (estimated)
Study Completion 2026-07-09 (estimated)
Updated on ClinicalTrials.gov 2026-07-29