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Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Study acronym: TRANSCEND
StatusRecruiting
PhasePhase 2
Started2025-04-01
View on ClinicalTrials.gov ↗

Amendment history

2026-07-29
Study Status, Eligibility, Contacts/Locations, Document Section v3
Eligibility criteria-7 characters
[...] Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaire25questionnaire Moderate-to-severe neuropathic pain determined by Patient R [...] ment Information System (PROMIS) Pain Interference score of >≥ 602660, as well as mean pain intensity scores >≥ 5 on a numeric rating scale27scale Previous trials of at least two medications recommended in [...] oral medication; Individuals with an eGFR above 40mL/min/1.73m273m² and all blood work on clinical laboratory tests assessed as [...] as assessed by a urine pregnancy test at Screening (V1) or individual'sindividuals that intend to become pregnant dur [...]
Study sitescontacts updated at 1 of 1 site
2025-04-23
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-03→confirmed 2025-04-01
Study sitesdetails revised at 1 of 1 site
2025-02-10
Study Status v1
Primary completion date2026-09→2027-03
Completion date2026-09→2027-12
Start date2024-09→2025-03
2024-07-22
Original filing
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. The purpose of this study is to assess the feasibility, tolerability, and preliminary efficacy of psilocybin therapy for adults with chronic neuropathic pain and co-morbid treatment resistant depression.
Trial Details
NCT Number NCT06518720
Lead Sponsor Centre for Addiction and Mental Health
Conditions Treatment Resistant Depression, Chronic Pain
Enrollment 16 participants
Start Date 2025-04-01
Primary Completion 2027-03 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-07-30