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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Enrollment closed, study ongoing Enrollment target: estimated 269 to confirmed 274 · Site details revised at 270 of 270 sitesv15 Show 2 more changesShow less
    • Enrollment target: estimated 269 to confirmed 274
    • Site details revised at 270 of 270 sites
  2. Completion pushed from Jun 30, 2028 to Jun 30, 2033v14
  3. Trial sites expanded: 263 → 270 locationsv13
  4. Site details revised at 1 of 263 sitesv12
  5. Trial sites expanded: 242 → 263 locationsv11
Show 9 earlier versionsHide 9 earlier versions
  1. Study sites: 234 to 242v10
  2. Study sites: 223 to 234v9
  3. Study sites: 198 to 223v8
  4. Study sites: 187 to 198v7
  5. Study sites: 136 to 187v6
  6. Start date: Aug 28, 2024 to Dec 12, 2024 Study sites: 99 to 136 · Completion date: Jun 30, 2033 to Jun 30, 2028 · Eligibility criteria expanded, about 2 words · 1 morev5 Show 4 more changesShow less
    • Study sites: 99 to 136
    • Completion date: Jun 30, 2033 to Jun 30, 2028
    • Eligibility criteria expanded, about 2 words
    • Collaborators shortened, about 4 words

    See this version in full on ClinicalTrials.gov ↗

  7. Study sites: 60 to 99v4
  8. Study sites: 13 to 60v3
  9. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 13 · Start date changed from estimate of Aug 30, 2024 to Aug 28, 2024v2 Show 2 more changesShow less
    • Study sites: 0 to 13
    • Start date changed from estimate of Aug 30, 2024 to Aug 28, 2024
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
NRG Oncology
67 trials monitored
See 5 trials at risk
Breast Cancer
5,213 trials monitored
See 271 trials at risk
Lung Cancer
4,057 trials monitored
See 217 trials at risk
Non-Small Cell Lung Cancer (NSCLC)
2,932 trials monitored
See 157 trials at risk
and 2 more diseases
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.
Trial Details
NCT Number NCT06500455
Lead Sponsor NRG Oncology
Conditions Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Renal Cell Carcinoma +2 more
Enrollment 274 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov