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Stroke Prevention In Ischemic Stroke With Covert Atrial Fibrillation

Study acronym: SPICAF
StatusRecruiting
PhasePhase 4
Started2025-06-18
View on ClinicalTrials.gov ↗

Amendment history

2026-06-03
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2025-09-01→2028-12-18
Completion date2028-03-01→2028-12-18
Start dateestimated 2024-09-01→confirmed 2025-06-18
Study sites0→1
2024-06-26
minor
Original filing
Patients who have recently had an ischemic stroke with no clear cause might have undetected atrial fibrillation (AF) that isn't caught during their initial hospital stay. After discharge, these patients are typically monitored for AF using devices like Holter monitors or implantable loop recorders. Treatment options during this period include anticoagulants or aspirin. Anticoagulants are more effective in preventing recurrent strokes if AF is present, offering an 80% risk reduction compared to aspirin's 20%. If AF is detected, anticoagulant treatment continues; if not, patients may switch to aspirin after 6-12 months. Despite the clinical rationale for using anticoagulants during this search period, their benefit-risk ratio compared to aspirin has not been fully evaluated.
Trial Details
NCT Number NCT06486792
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Conditions Stroke, Ischemic Stroke, Cerebral Infarction, Atrial Fibrillation
Enrollment 1,148 participants
Start Date 2025-06-18
Primary Completion 2028-12-18 (estimated)
Study Completion 2028-12-18 (estimated)
Updated on ClinicalTrials.gov 2026-06-05