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Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest

Study acronym: RIPOST-CA
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Re-verified, no change to tracked fieldsv12
  2. Primary completion pushed from Jan 2027 to Jan 2028
    • Study completion pushed from Apr 2027 to Apr 2028
    • Eligibility criteria expanded, about 10 words
    • Study description revised
    v11
  3. 6 versions Re-verified since Aug 4, 2025, no change to tracked fieldsv5-v10
  4. Trial status: Not Yet Recruiting to Recruitingv4 Show 4 more changesShow less
    • Primary completion date: Dec 2026 to Jan 2027
    • Study completion date: Mar 2027 to Apr 2027
    • Start date changed from estimate of Dec 2024 to Jan 11, 2025
    • Site details revised
  5. Start date: Oct 2024 to Dec 2024
    • Primary completion date: Oct 2026 to Dec 2026
    • Study completion date: Jan 2027 to Mar 2027
    v3
  6. Re-verified, no change to tracked fieldsv2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain injury. Despite current recommended advanced life support therapies, no specific treatment or procedure has yet been shown to improve the neurological outcome of such patients. Remote ischemic post-conditioning (RIPOST) which usually consists of applying brief and repeated cycles of ischemia alternating with reperfusion by inflating and deflating a blood pressure cuff or a pneumatic tourniquet placed around a limb, is a promising strategy to protect organs against I/R injury, including brain. Regarding cardiac arrest, pre-clinical studies have demonstrated an improvement in neurological outcome in animal subjects treated with RIPOST after cardiopulmonary resuscitation. The aim of our study is to demonstrate the benefit of early RIPOST in OHCA patients in reducing neurological injury and organ failure related to I/R syndrome.
Trial Details
NCT Number NCT06473207
Lead Sponsor Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Collaborators: French Society for Intensive Care
Conditions
(from sponsor)		 Out-Of-Hospital Cardiac Arrest
Related terms Heart Arrest, Out-of-Hospital Cardiac Arrest
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov