Clinical Trial

SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC

Study acronym: SHARP
Recruiting Phase 3
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Summary
This phase III trial compares the effect of stereotactic radiosurgery and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-06-10; most recent amendment 2025-07-12.
Trial Details
NCT Number NCT06457906
Lead Sponsor Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions Small-cell Lung Cancer, Brain Metastases, SRS, Stereotactic Radiotherapy, Whole Brain Radiotherpay, Hippocampal-avoidance
Enrollment 340 participants
Start Date 2023-09-01
Primary Completion 2027-08-30 (estimated)
Study Completion 2028-02-28 (estimated)
Updated on ClinicalTrials.gov 2025-07-16