Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)

Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation dose is administered to the cancerous tumor, not the vital body organs. Potential participants with a sarcoma diagnosis will be referred to Radiation Oncology during this study. If the participant is interested in participating in this study, s/he receives radiation treatment daily for 5 consecutive days except for weekends and holidays. Within 12 weeks of completing the radiation therapy, the participant will have the primary tumor surgically removed. The radiation oncology team will follow the patients for 5 years after completing radiation therapy.

NCT Number	NCT06436612
Lead Sponsor	Jonsson Comprehensive Cancer Center
Conditions	Abdominopelvic Sarcomas
Enrollment	20 participants
Start Date	2024-05-30
Primary Completion	2027-05-30 (estimated)
Study Completion	2028-05-26 (estimated)
Updated on ClinicalTrials.gov	2026-06-05