Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols

There is a significant unmet need for optimized treatment in rhabdomyolysis. There are few prospective interventional studies on treatment for rhabdomyolysis, a condition which affects diverse and underrepresented populations at a higher rate. While steroids are often used off-label, a systematic study has not yet been initiated, and steroids have not been yet considered in as a consideration to standard care guidelines. The hypothesis is that patients who receive dexamethasone in addition to standard care versus placebo and standard care will have improvement in pain, length of hospital stay, and decrease in kidney complications.

NCT Number	NCT06429982
Lead Sponsor	Children's National Research Institute
Conditions	Rhabdomyolysis
Enrollment	50 participants
Start Date	2024-10-01
Primary Completion	2025-12-01 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-07-03