Clinical Trial

Thermogenic Silencer Regulatory Factors in Humans

Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST). A critical limitation with NST as a therapeutic option, however, is that this beneficial process is silenced under human physiological temperature conditions and the mechanisms of how this occurs is unknown. This study will be the first to identify human NST silencing factors that may be targeted for the treatment of obesity and metabolic disorders.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-05-15; most recent amendment 2026-04-09.
Status change: Recruiting → Active, Not Recruiting 2026-04-09
Status change: Not Yet Recruiting → Recruiting 2025-03-19
Trial Details
NCT Number NCT06424132
Lead Sponsor Rockefeller University
Collaborators: Cornell University
Conditions Obesity, Metabolic Disease, Cold Exposure
Enrollment 8 participants
Start Date 2024-08-16
Primary Completion 2026-12-04 (estimated)
Study Completion 2026-12-04 (estimated)
Updated on ClinicalTrials.gov 2026-04-14