Valve Performance of the SAPIEN 3 Ultra RESILIA Valve: A Prospective Registry With Central Echocardiography Analysis.

The issue of valve durability has become one of the most important aspects in the TAVR field in recent years since transcatheter aortic valve replacement has been progressively applied to younger patients with a low co-morbidity burden. The SAPIEN 3 Ultra RESILIA valve represents the last generation of the SAPIEN valve system and includes several important iterations (newer leaflet calcium-blocking technology targeting calcium-attracting free aldehydes, dry tissue storage, newer skirt textile design) that should translate into a favorable impact on valve durability at mid- to long- term follow-up

NCT Number	NCT06420830
Lead Sponsor	Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Conditions	Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Enrollment	150 participants
Start Date	2024-05-16
Primary Completion	2026-10-01 (estimated)
Study Completion	2034-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-27