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Cytokine Alterations and Chronic Post-Surgical Pain

StatusWithdrawn
PhaseNot specified
Started2026-01-01
View on ClinicalTrials.gov ↗

Amendment history

2026-09-23
critical
Withdrawn before enrolling
Trial withdrawn: Was unable to achieve funding for this study
2025-08-27
minor
Study Identification, Study Status v4
Primary completion date2026-12-01→2028-12-01
Completion date2026-12-31→2028-12-31
Start date2025-07-01→2026-01-01
2025-03-04
minor
Study Identification, Study Status, Oversight v3
Start date2025-01-01→2025-07-01
2024-09-24
minor
Study Status, References v2
Publications12 to 6 entries
Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007 Spring;45(2):27-37. doi: 10.1097/AIA.0b013e318034194e. Odell DW. Epigenetics of pain mediators. Curr Opin Anaesthesiol. 2018 Aug;31(4):402-406. doi: 10.1097/ACO.0000000000000613. Guertin JR, Page MG, Tarride JE, Talbot D, [...]
2024-08-12
minor
Study Status, Study Description, Study Design, Arms and Interventions, Eligibility, References v1
InterventionsUnilateral thoracotomy for non-malignant lung resection (Other)→Unilateral thoracotomy (Other)
Eligibility criteria+164 characters
[...] vide informed consent for study participation. Patient with lungmalignancy cancerthat needs thoracotomy for surgical resection. Exclusion Criteria: Chronic pain prior to surgery Pre-existing fibromyalgia Long-term opioid use Diabetes mellitus Inflammatory bowel disease Pre-existing neurological disease Pre-existing nerve injury [...] pation Malignancy other than lung cancer Autoimmune disorder (e.g. rheumatoid arthritis and psoriatic arthritis) Pregnancy Inability to communicate in the English language ( [...] or completion of questionnaires and provision of pain scores). Patents on antiepileptic medicatio [...]
Study description-31 characters
[...] ic infection or pain from a chronic condition preceding the surgery1surgery. This condition negatively impacts health related quality o [...] n to hernia repair, are prone to develop CPSP with variable incidences2incidences. CPSP may be a result of peripheral and central sensitizati [...] ncluding nerve growth factors (NGF) and interleukins (IL-1β)3. Specific regulatory mechanisms leading to augmented synthe [...] lteration of gene expression without any structural genomic alterations4,5alterations that may regulate cytokine production at the transcriptional and post transcriptional levels6levels. Among these list [...] [...]
Publications7 to 12 entries
Guertin JR, Page MG, Tarride JE, Talbot D, Watt-Watson J, Choiniere M. Just how much does it cost? A cost study of chronic pain following cardiac surgery. J Pain Res. 2018 Nov 8;11:2741-2759. doi: 10.2147/JPR.S175090. eCollection 2018. Parsons B, Schaefer C, Mann R, Sadosky A, Daniel S, Nalamachu S, [...]
2024-05-13
minor
Original filing
Chronic Post-Surgical Pain (CPSP) is a condition that involves experiencing pain and/or discomfort that lasts for more than 3 months following surgery without any explainable cause of this pain such chronic infection or pain caused from a condition preceding surgery. This condition negatively impacts health related quality of life and is associated with significant financial burden both for the patient and health care system. Patients undergoing common surgeries such as amputation, breast surgery, hernia repair, coronary artery bypass, and caesarean section can be prone to developing CPSP. CPSP may be caused by the release and expression of different cellular molecules called cytokines and chemokines that can cause a pain response when they are present in the body at certain levels. After surgical incision, tissue cells have been shown to release cytokines and chemokines, thus increasing the concentration of these molecules in the patient's blood. It is not entirely known what mechanisms cause the increased expression of chemokines and cytokines. One method that may play a role in in this expression is epigenetics which is the alteration of gene expression without permanently altering the structure of DNA. Unlike mutations, epigenetic changes are dynamic, possibly reversible, and are influenced by environmental and behavioral changes such as diet, exercise, disease, stress, toxin exposure etc. Epigenetic changes occur all throughout our life and have been associated with several disease processes such as cancer, diabetic complications, and chronic pain. At the molecular level, certain events take place that can regulate (increase or decrease) the expression of cytokines and chemokines, most notably DNA methylation of their promotor (which involves adding molecules to DNA that does not change its structure but changes it's activity). The investigators are conducting this study to determine if the alteration of specific cytokines are associated with the occurrence of CPSP and whether these cytokines are regulated by DNA methylation at their promoter. This study will take place at London Health Sciences Centre and will recruit up to 60 patients who will be undergoing a thoracotomy procedure (surgery of the chest area).
Trial Details
NCT Number NCT06418295
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions Chronic Post Operative Pain
Start Date 2026-01-01
Primary Completion 2028-12-01 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-09-22