Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA). Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups.

NCT Number	NCT06384651
Lead Sponsor	The Methodist Hospital Research Institute
Conditions	Infections, Ankle Arthritis
Enrollment	40 participants
Start Date	2024-12-03
Primary Completion	2027-04 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2025-01-24