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DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease

Study acronym: DIAN-TU
StatusActive, Not Recruiting
PhasePhase 3
Started2024-06-10
View on ClinicalTrials.gov ↗
This is an open label study to treat dominantly inherited Alzheimer's disease (DIAD) mutation carrier participants from the DIAN-TU-001 gantenerumab Open Label Extension (OLE) period with lecanemab to determine the effects of amyloid removal on age of onset and clinical progression compared to external controls, if amyloid plaque as measured by amyloid PET can be fully removed in DIAD, and the effects of amyloid removal on biomarkers of disease progression.

Amendment record

Amended 7 times since 2024-04-22; most recent filed 2026-07-23. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-30.

2026-07-23
Amendment Study Status v7
2026-03-04
Amendment Study Status, Study Design v6
2026-02-11
Amendment Study Status v5
2025-11-10
Amendment Recruiting→Active, Not Recruiting Study Status, Oversight, Study Design, Contacts/Locations v4
2025-07-30
Amendment Study Status, Oversight, Contacts/Locations v3
2025-03-30
Amendment Study Status, Contacts/Locations v2
2024-07-01
Amendment Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
2024-04-22
Original filing
Trial Details
NCT Number NCT06384573
Lead Sponsor Washington University School of Medicine
Collaborators: Alzheimer's Association, Eisai Inc.
Conditions Alzheimer's Disease, Dementia, Alzheimer's Disease, Familial
Enrollment 40 participants
Start Date 2024-06-10
Primary Completion 2030-06 (estimated)
Study Completion 2030-06 (estimated)
Updated on ClinicalTrials.gov 2026-07-27