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Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp

Study acronym: PREGnant
StatusActive, Not Recruiting
PhasePhase 3
Started2024-03-16
View on ClinicalTrials.gov ↗

Amendment history

2026-06-03
Recruiting→Active, Not Recruiting Study Status, Oversight, Study Design, Contacts/Locations v4
Trial statusRecruiting→Active, Not Recruiting
Primary completion date2026-06-30→2027-03-31
Completion date2026-09-30→2027-03-31
Enrollment targetestimated 297→confirmed 97
Study sitesdetails revised at 5 of 5 sites
2025-07-21
Study Identification, Study Status, Study Design v3
Enrollment target288→297
2025-03-06
Study Status, Oversight, Contacts/Locations v2
Completion date2026-06-30→2026-09-30
Study sitescontacts updated at 3 of 5 sites
2024-04-18
Study Status, Arms and Interventions, IPDSharing v1
Re-verified, no change to tracked fields
2024-04-16
Original filing
Yale University
487 trials monitored
See 35 trials at risk
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET), live birth rates will improve in those pretreated with GnRH antagonist compared to those not pretreated with GnRH antagonist.
Trial Details
NCT Number NCT06375811
Lead Sponsor Yale University
Collaborators: University of Colorado, Denver, Northwestern University, University of North Carolina, Duke University, Johns Hopkins University
Conditions Infertility, Endometriosis
Enrollment 97 participants
Start Date 2024-03-16
Primary Completion 2027-03-31 (estimated)
Study Completion 2027-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-05