Estrogen Deficiency on Cardiovascular Risk

To explore how estrogen deficiency impacts the blood pressure (BP) and sympathetic nerve activity (SNA), and how it impacts the production of the key pro-inflammatory mediators such as Tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). It is hypothesized that estrogen deficiency increases BP, SNA and the pathway activities of the key pro-inflammatory mediators. Those effects are impacted through the downregulation of the estrogen receptor.

NCT Number	NCT06369363
Lead Sponsor	Milton S. Hershey Medical Center
Conditions	Postmenopausal Symptoms, Cardiovascular Diseases
Enrollment	20 participants
Start Date	2026-09
Primary Completion	2028-09 (estimated)
Study Completion	2028-11 (estimated)
Updated on ClinicalTrials.gov	2025-11-17