Pilot Study of the Human Metagenome in Metabolic Diseases

This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia. Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing. We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.

NCT Number	NCT06363253
Lead Sponsor	Sengkang General Hospital Collaborators: Singapore General Hospital, Nanyang Technological University, Duke-NUS Graduate Medical School
Conditions	Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation, Metabolic Syndrome
Enrollment	600 participants
Start Date	2023-08-14
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-05-15