Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis

This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.

NCT Number	NCT06339190
Lead Sponsor	Monash University Collaborators: Eastern Health, University of Melbourne, Wake Forest University, Deakin University, The Florey Institute of Neuroscience and Mental Health, Invitae Corporation, Redenlab
Conditions	Neurodegenerative Diseases, Dementia
Enrollment	1,000 participants
Start Date	2021-08-01
Primary Completion	2025-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2025-05-30