Anesthesia and Non-small Cell Lung Cancer Recurrence

There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of NSCLC is higher in patient who received total intravenous anesthesia (TIVA) than volatile anesthetics in this multi-center randomized trials.

NCT Number	NCT06330038
Lead Sponsor	Samsung Medical Center Collaborators: Seoul National University Hospital, Asan Medical Center, Severance Hospital, Seoul St. Mary's Hospital, Korea University Guro Hospital, DongGuk University, Inha University Hospital, Konkuk University Medical Center, Ewha Womans University, Chungnam National University Hospital, University of Virginia, Memorial Sloan Kettering Cancer Center, Yale University, Mayo Clinic, University of Texas Southwestern Medical Center, University Hospitals Coventry and Warwickshire NHS Trust, Khon Kaen University, King Chulalongkorn Memorial Hospital, The Affiliated Hospital of Qingdao University, Beijing Hospital, All India Institute of Medical Sciences
Conditions	Non-small Cell Lung Cancer, Surgery, Anesthesia
Enrollment	5,384 participants
Start Date	2024-08-05
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-20