Clinical Trial

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

Recruiting Phase 4
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Summary
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based methadone.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2024-03-14; most recent amendment 2026-04-29.
Status change: Not Yet Recruiting → Recruiting 2024-05-21
Trial Details
NCT Number NCT06323824
Lead Sponsor Yale University
Collaborators: National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA), The Emmes Company, LLC, University of California, San Francisco, Boston Medical Center (BMC), Hennepin Healthcare Research Institute, Alameda Health System, Marshall Health, Kaiser Permanente
Conditions Opioid Use Disorder
Enrollment 600 participants
Start Date 2024-06-04
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-05