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Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids

Study acronym: BRAINS
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. 2 versions Re-verified since Mar 25, 2025, no change to tracked fieldsv5-v6
  2. Start date changed from estimate of May 1, 2024 to May 17, 2024v4
  3. Start date: Mar 1, 2024 to May 1, 2024v3
  4. Secondary endpoints: details revised at 1 of 3 entriesv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Wayne State University
48 trials monitored
See 1 trial at risk
Anxiety
3,263 trials monitored
See 159 trials at risk
Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. This study will test whether a behavioral intervention, acute exercise, can help to improve fear regulation by enhancing brain activity and endocannabinoid signaling. This line of research may ultimately lead to more effect treatments for adolescent anxiety, and to new preventive strategies for at-risk youth.
Trial Details
NCT Number NCT06297278
Lead Sponsor Wayne State University
Collaborators: National Institute of Mental Health (NIMH)
Conditions
(from sponsor)		 Adolescence
Related terms Anxiety Disorders, Motor Activity
Enrollment 174 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov