Prognotic Role of CMR in Takotsubo Syndrome

The primary objective of this observational registry is to develop a comprehensive clinical and imaging score (incorporating echocardiography and cardiac magnetic resonance data) that enhances risk stratification for patients with Takotsubo syndrome. The secondary objectives of this registry are as follows: Investigate the diagnostic value of cardiac magnetic resonance parameters in predicting in-hospital and long-term outcomes in patients with Takotsubo syndrome. Compare the proposed risk stratification score for patients with Takotsubo syndrome with previously existing scores. Investigate the contribution of machine learning models in predicting in-hospital and long-term outcomes compared to standard clinical scores. The design and rationale of this registry are available at 10.1097/RTI.0000000000000709

NCT Number	NCT06277297
Lead Sponsor	University of Cagliari Collaborators: Centro Cardiologico Monzino, IRCCS San Raffaele, University of Roma La Sapienza, Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy, University of Messina, University of Udine, Vannini Hospital Rome, A.O.U. Città della Salute e della Scienza - Molinette Hospital, University Hospital, Bonn, University Hospital, Rouen
Conditions	Takotsubo Cardiomyopathy, Machine Learning, Magnetic Resonance Imaging
Enrollment	350 participants
Start Date	2022-11-09
Primary Completion	2026-11 (estimated)
Study Completion	2032-11 (estimated)
Updated on ClinicalTrials.gov	2025-06-08