Intermittent Hypoxia in Persons With Multiple Sclerosis

This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.

NCT Number	NCT06276634
Lead Sponsor	Shirley Ryan AbilityLab Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Northwestern University
Conditions	Multiple Sclerosis, Multiple Sclerosis-Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
Enrollment	21 participants
Start Date	2024-04-30
Primary Completion	2025-11-03 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-20