Evaluation of A Clinical Diagnostic Test for CRDS

Calcium Release Deficiency Syndrome (CRDS) is a novel inherited arrhythmia syndrome secondary to RyR2 loss-of-function that confers a risk of sudden cardiac death. Diagnosis of CRDS presently requires cellular-based in vitro confirmation that an RyR2 variant causes loss-of-function. We hypothesize that CRDS can be diagnosed clinically through evaluation of the repolarization response to brief tachycardia, mediated by cardiac pacing, and a subsequent pause.

NCT Number	NCT06188689
Lead Sponsor	Population Health Research Institute Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions	Calcium Release Deficiency Syndrome (CRDS)
Enrollment	400 participants
Start Date	2023-02-02
Primary Completion	2027-12 (estimated)
Study Completion	2028-03 (estimated)
Updated on ClinicalTrials.gov	2026-07-22