The French Gut-colo

Colorectal cancer (CRC) is the second most common type of cancer worldwide. The European Union recommends national CRC screening for people aged between 50 and 74. Generally, an immunological test called FIT (Fecal Immunochemical Test), based on the quantitative detection of human haemoglobin, is performed on a stool sample. If the haemoglobin level is above the recommended threshold, a colonoscopy is recommended to detect colorectal lesions. Recent studies have identified potential microbiota signatures associated with colon cancer. In this study, we will analyze the microbiota of a population aged 50 to 75 years undergoing colonoscopy as part of routine care in order to confirm the presence of microbiota signatures associated with the presence of adenomas, advanced adenomas and CRC.

NCT Number	NCT06174233
Lead Sponsor	Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement Collaborators: Assistance Publique - Hôpitaux de Paris
Conditions	Patients Aged 50-75 and Requiring Colonoscopy
Enrollment	2,500 participants
Start Date	2024-06-26
Primary Completion	2028-06-25 (estimated)
Study Completion	2028-06-25 (estimated)
Updated on ClinicalTrials.gov	2025-09-16