Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)

Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer. To contribute to a better understanding of the neural and inflammatory mechanisms underlying this issue, we aim to implement a novel intervention based on the preoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) with or without an anti-epileptic drug. Our goal is to understand and transform the perioperative window from being a facilitator of metastatic progression to arresting and/or eliminating residual disease using repurposing drugs

NCT Number	NCT06150898
Lead Sponsor	Jules Bordet Institute Collaborators: KU Leuven
Conditions	Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer
Enrollment	112 participants
Start Date	2025-05-12
Primary Completion	2027-04-20 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2025-06-13