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French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis

Study acronym: FG-CoALS
StatusRecruiting
PhaseNot applicable
Started2024-09-17
View on ClinicalTrials.gov ↗

Amendment history

2026-08-05
Study Status, Contacts/Locations v3
Study sites7→9
2026-06-19
Study Status v2
Re-verified, no change to tracked fields
2024-11-21
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2026-12-31→2027-09-30
Completion date2028-03-31→2029-09-30
Start dateestimated 2024-01-20→confirmed 2024-09-17
Study sites1→7
2023-11-18
Original filing
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS. Participants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.
Trial Details
NCT Number NCT06147843
Lead Sponsor University Hospital, Limoges
Collaborators: National Research Agency, France, Centre de Recherche en biomédecine de Strasbourg INSERM UMR-S1118, Paris Brain Institute (ICM), Institut National de la Santé et de la Recherche Médical - délégation Grand Ouest INSERM U1253, Klinik für Neurologie, Universitäts- und Rehabilitationskliniken Ulm (RKU), Centre de Données Cliniques et de Recherche CDCR, UMR Inserm U1253-IBRain-Neurogénétique et Physiopathologie Neuronale, France Cohorte
Conditions Amyotrophic Lateral Sclerosis
Enrollment 1,000 participants
Start Date 2024-09-17
Primary Completion 2027-09-30 (estimated)
Study Completion 2029-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-06