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ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL

StatusRecruiting
PhasePhase 4
Started2023-12-01
View on ClinicalTrials.gov ↗

Amendment history

2026-07-10
Study Identification, Study Status, Contacts/Locations v2
Primary completion date2026-01-31→2027-06-30
Completion date2026-01-31→2027-06-30
Study sitescontacts updated at 1 of 1 site
Study titlerevised
ED90 of Bupivacaine After Lidocaine Test Dose withWith DPE and EPL
2025-02-06
Not Yet Recruiting→Recruiting Study Identification, Study Status, Oversight, Study Description, Study Design, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
PhaseNot applicable→Phase 4
Primary completion date2024-12-31→2026-01-31
Completion date2025-12-31→2026-01-31
Study sites0→1
Study description+15 characters
WeThe investigators will be conducting a randomized controlled trial with patie [...]
Study titlerevised
ED90 of Bupivacaine After Lidocaine Test Dose Withwith DPE and EPL
2023-11-18
Original filing
The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial effective comfort in 90% of patients (post test-dose ED90) via the epidural (DPE or EPL) technique in women undergoing labor induction or augmentation; the investigators hypothesize that the investigators will be able to determine the post test-dose ED90 of bupivacaine for each technique with adequate precision to inform the optimal doses to study in a subsequent randomized trial comparing the analgesic effects of DPE vs. EPL. The investigators also hypothesize that the post test-dose ED90 of bupivacaine is lower with a DPE technique than with a conventional epidural technique.
Trial Details
NCT Number NCT06146842
Lead Sponsor Brigham and Women's Hospital
Conditions Labor Pain
Enrollment 120 participants
Start Date 2023-12-01
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-13