Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery

All patients will be completed collection of demographic data, clinical data, and be observed for inflammatory organ damage, oxygenation index or SpO2/ FIO2, WBC, NEU, interleukin-1β, interleukin-6, interleukin-8 (IL-1β/6/8), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), procalcitonin (PCT), myoglobin (Myo), creatine kinase-MB (CK-MB), high-sensitivity cardiac troponin T (hs-cTnT), neutrophil elastase (NE), myeloperoxidase (MPO), APACHE II score, alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin, Murray lung injury score, serum creatinine, eGFR, mechanical ventilation time, ICU length of stay, drug-related gastrointestinal reactions, and 30-day and 90-day all-cause mortality, among other indicators.

NCT Number	NCT06118034
Lead Sponsor	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Collaborators: First Affiliated Hospital of Zhejiang University, Jinan Central Hospital, The First People's Hospital of Changzhou, Xinhua hospital of ILi in Kazakhstan automomous district, First Affiliated Hospital of Harbin Medical University, Yangzhou University, Shandong Provincial Hospital, Huai'an First People's Hospital, The First Affilated Hospital of the Medical College, Shihezi University, Affiliated Hospital of Nantong University
Conditions	Inflammatory Response, Cardiac Disease
Enrollment	768 participants
Start Date	2024-01-28
Primary Completion	2026-08-31 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-11-17