Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

This phase II trial tests how well fisetin and exercise works in preventing frailty in breast cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement. Nutritional supplements may be useful in eliminating cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with breast cancer undergoing physical activity.

NCT Number	NCT06113016
Lead Sponsor	Jonsson Comprehensive Cancer Center Collaborators: National Institutes of Health (NIH), National Cancer Institute (NCI), Rising Tide Foundation
Conditions	Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Early Stage Breast Carcinoma
Enrollment	164 participants
Start Date	2024-07-23
Primary Completion	2028-10-31 (estimated)
Study Completion	2031-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-30