Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology

Cirrhotic cardiomyopathy is associated with increased risk of complications like hepatorenal syndrome, refractory ascites, impaired response to stressors including sepsis, bleeding or transplantation, poor health related quality of life and increased morbidity and mortality. Left ventricular diastolic dysfunction (LVDD) is associated with risk of hepatorenal syndrome (HRS) , septic shock. , heart failure in the perioperative period following liver transplantation, and after trans-jugular intrahepatic portosystemic shunt (TIPS) insertion . The echocardiographic E/e' ratio is a predictor of survival in LVDD, with multiple studies, including prospective data from our Centre.

NCT Number	NCT06095466
Lead Sponsor	Post Graduate Institute of Medical Education and Research, Chandigarh
Conditions	Cirrhotic Cardiomyopathy, Cirrhosis, Liver, Cardiac Disease
Enrollment	150 participants
Start Date	2023-07-15
Primary Completion	2026-08-15 (estimated)
Study Completion	2026-10-15 (estimated)
Updated on ClinicalTrials.gov	2023-10-23