Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.

[...] r study investigator) ALT/AST < 3 x ULN Bilirubin < 2 x ULN No supplemental oxygen at rest Note: Pulmonary Function Test (PFT) only required per treating physician discretion. Adequate cardiac function with a DLCOEF of ≥50%. This will not have to be repeated if within 45 days of initial assessment. Adequate echocardiogram with EF of ≥50% This will not have to be repeated if within 45 days of initial assessment. Adequate venous access for apheresis and no other contraindi [...] this route pertains extremely minimal systemic penetration Any previous treatment with any gene therapy products Any uncontr [...] [...]

in vivo persistence of a single dose of the CD4CAR in patientssubjects with CMML

[...] ing this into account, the investigators expect to treat 15 patientssubjects. The study will utilize autologous CD4CAR T-cells that are [...] utilizing standard prophylaxis recommended for HIV-positive patientssubjects with T-cell aplasia and those undergoing allogeneic stem ce [...] ort- and intermediate-term evaluations are performed, these patientssubjects will enter a rollover study to assess for disease-free surv [...] e escalation in phase I is to avoid unnecessary exposure of patientssubjects to sub-therapeutic doses (i.e., to treat as many patientssubjects as possible within the therapeutic dose range) wh [...] [...]

[...] in < 2 x ULN Pulmonary Function Test (PFT) with a DLCO of ≥ 6050%. This will not have to be repeated if within 45 days of in [...] nd permitted by the Principal Investigator Participation in anothera cell/gene therapy clinical study with an investigational product within the past 6 months; and/or no other clinical trial with an investigational product within the last 4 weeks, provided subject was in fact given that experimental treatment, just being enrolled and treated is not a disqualifier. Eligibility for cd4CAR Infusion Afebrile and not receiving [...] eed not be repeated if within 45 days of initial a [...]