Propranolol in Primary Progressive Aphasia

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

NCT Number	NCT06066710
Lead Sponsor	University of Missouri-Columbia
Conditions	Aphasia, Primary Progressive
Enrollment	30 participants
Start Date	2025-01-13
Primary Completion	2026-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-17