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Somatic Mosaicism in Twins Discordant for Childhood Cancer

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Jun 30, 2026 → Jun 30, 2027
See other at-risk trials from Children's Oncology Group

Record History

  1. Primary completion pushed from Jun 30, 2026 to Jun 30, 2027 Lead sponsor: Children's Oncology Group to Children's Oncology Group · Eligibility criteria expanded, about 6 words · Secondary endpoints: details revised at 1 of 1 entry Show 3 more changesShow less
    • Lead sponsor: Children's Oncology Group to Children's Oncology Group
    • Eligibility criteria expanded, about 6 words
    • Secondary endpoints: details revised at 1 of 1 entry
  2. Primary completion date: Oct 5, 2025 to Jun 30, 2026 Completion date: Dec 31, 2025 to Jun 30, 2027v6 Show 1 more changeShow less
    • Completion date: Dec 31, 2025 to Jun 30, 2027
  3. Re-verified, no change to tracked fieldsv5
  4. Start date: Sep 29, 2023 to Jun 3, 2024v4
  5. Primary completion date: Sep 30, 2026 to Oct 5, 2025 Completion date: Sep 30, 2026 to Dec 31, 2025 · Start date changed from estimate of Oct 6, 2023 to Sep 29, 2023v3 Show 2 more changesShow less
    • Completion date: Sep 30, 2026 to Dec 31, 2025
    • Start date changed from estimate of Oct 6, 2023 to Sep 29, 2023
  6. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1v2 Show 1 more changeShow less
    • Study sites: 0 to 1
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
Trial Details
NCT Number NCT06054295
Lead Sponsor Children's Oncology Group
Collaborators: National Cancer Institute (NCI)
Conditions Pediatric Central Nervous System Tumor, Central Nervous System Tumor, Discordant Twin, Somatic Mutation
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov