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NAC vs Placebo on Opioid Use for Hysterectomy

StatusCompleted
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Minor Trial completed Primary completion date changed from estimate of Nov 25, 2026 to Aug 15, 2026 · Study completion date changed from estimate of Dec 9, 2026 to Aug 26, 2026 · Eligibility criteria expanded, about 9 words · 2 more Show 5 more changesShow less
    • Primary completion date changed from estimate of Nov 25, 2026 to Aug 15, 2026
    • Study completion date changed from estimate of Dec 9, 2026 to Aug 26, 2026
    • Eligibility criteria expanded, about 9 words
    • Secondary endpoints: details revised at 1 of 1 entry
    • Site details revised
  2. Notable Primary completion date: Sep 25, 2025 to Nov 25, 2026 Completion date: Oct 9, 2025 to Dec 9, 2026 · Site contact updatedv5 Show 2 more changesShow less
    • Completion date: Oct 9, 2025 to Dec 9, 2026
    • Site contact updated
  3. Minor Site contact updatedv4
  4. Notable Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1 · Start date changed from estimate of Nov 17, 2023 to Nov 30, 2023v3 Show 2 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Nov 17, 2023 to Nov 30, 2023
  5. Notable Start date: Sep 25, 2023 to Nov 17, 2023v2
  6. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will enroll females who are ages 18 and older undergoing a laparoscopic or robotic, partial or full hysterectomy. Participants will be randomized to receive IV n-acetylcysteine or placebo during the first 60 minutes of their procedure. At various time points after the procedure patients will be asked to report their pain scores, and any pain medication taken.
Trial Details
NCT Number NCT06039566
Lead Sponsor Medical University of South Carolina
Conditions Hysterectomy
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov