Clinical Trial

De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

Study acronym: DIREKHT2
Recruiting Phase 2/3
View on ClinicalTrials.gov →
Summary
This randomized, prospective, multicenter phase II/III trial will study the reduction of radiation volume by eliminating radiotherapy (RT) to the elective neck using strictly defined surgical and radio-oncological standards to reduce radiotherapy-related long-term side effects without affecting locoregional control.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2023-09-08; most recent amendment 2026-03-11.
Status change: Not Yet Recruiting → Recruiting 2024-02-27
Trial Details
NCT Number NCT06030440
Lead Sponsor University of Erlangen-Nürnberg Medical School
Conditions Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of the Hypopharynx, Squamous Cell Carcinoma of the Oropharynx
Enrollment 508 participants
Start Date 2024-01-26
Primary Completion 2031-12 (estimated)
Study Completion 2033-09 (estimated)
Updated on ClinicalTrials.gov 2026-03-13