Omitting CTV for Locally Advanced NSCLC Responded to Immunotherapy and Chemotherapy

Radical radiotherapy is critical for locally advanced non small cell lung cancer(NSCLC ). Our previous sturdy indicated that patients who received induction immunotherapy and subsequent radiotherapy suffered higher proportion of pneumonitis.Grade 2 or more pneumonitis patients have worse prognosis. It is urged to optimize the radiotherapy dose and target volume for patients treated with immunotherapy and radiotherapy. According to retrospective and prospective studies, omitting CTV radiation is feasible for patients undergoing concurrent radio-chemotherapy for locally advanced NSCLC. It is postulated that omitting CTV radiation for patients responded to induction therapy with immunotherapy and chemotherapy will have less pneumonitis without sacrificing the local control rate. Omitting CTV may also retain better immune function which will facilitate the immunotherapy.

NCT Number	NCT06020430
Lead Sponsor	Hubei Cancer Hospital
Conditions	Non Small Cell Lung Cancer, Locally Advanced, Radiotherapy, Immunotherapy
Enrollment	134 participants
Start Date	2024-02-08
Primary Completion	2026-02-08 (estimated)
Study Completion	2027-10-08 (estimated)
Updated on ClinicalTrials.gov	2024-03-15