Small Extracellular Vesicles and Insulin Action

The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.

NCT Number	NCT05933707
Lead Sponsor	Washington University School of Medicine
Conditions	Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
Enrollment	72 participants
Start Date	2023-06-14
Primary Completion	2028-06-01 (estimated)
Study Completion	2028-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-17