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NCT05913882 · ClinicalTrials.gov record · last posted 2025-12-23

Combined Respiratory Training in Persons With ALS

StatusRecruiting
PhaseNot applicable
Started2023-08-22
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from the ClinicalTrials.gov record
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

Amendment record 3 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 3 times since 2023-06-13; most recent amendment 2025-12-16. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2023-08-22
Status change Not Yet Recruiting→Recruitingv1
Trial Details
NCT Number NCT05913882
Lead Sponsor Nova Southeastern University
Collaborators: Congressionally Directed Medical Research Programs
Conditions ALS, Respiratory Insufficiency, Dysphagia
Enrollment 34 participants
Start Date 2023-08-22
Primary Completion 2026-09-30 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-23