Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure

Patent foramen ovale PFO closure has been shown to reduce the risk of stroke in patients with recurrent stroke. However, the majority of existing clinical studies in this field excluded patients over the age of 60 years. Data in older patients is limited and since the population ages and stroke remains a major cause of death and morbidity, randomized clinical trials are needed to better assess the benefit of PFO closure in this elderly population. Therefore, this study proposal sought to determine the efficacy of PFO closure for the prevention of recurrent stroke in older patients with PFO and cryptogenic stroke.

NCT Number	NCT05907694
Lead Sponsor	Josep Rodes-Cabau
Conditions	Patent Foramen Ovale, Cryptogenic Stroke, Older Patients, Medical Treatment, Recurrent Stroke
Enrollment	714 participants
Start Date	2024-06-18
Primary Completion	2027-10-01 (estimated)
Study Completion	2037-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-27