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Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Mar 15, 2025 to Sep 19, 2025
    • Study sites: 2 to 1
    v9
  2. Primary completion date: Jan 2030 to Nov 1, 2028
    • Study completion date: Feb 2030 to Dec 1, 2028
    • Start date: Feb 20, 2025 to Mar 15, 2025
    • Site contacts updated at 2 of 2 sites
    v8
  3. Start date: Nov 1, 2024 to Feb 20, 2025
    • Primary completion date: Nov 2029 to Jan 2030
    • Study completion date: Dec 2029 to Feb 2030
    v7
  4. Lead sponsor: Weill Medical College of Cornell University to AdventHealthv6 Show 5 more changesShow less
    • Primary completion date: Nov 2028 to Nov 2029
    • Start date: Aug 1, 2024 to Nov 1, 2024
    • Study completion date: Dec 2028 to Dec 2029
    • Eligibility criteria shortened, about 7 words
    • Study sites revised (2)
  5. Start date: Apr 1, 2024 to Aug 1, 2024v5
Show 3 earlier versionsHide 3 earlier versions
  1. Start date: Apr 2024 to Apr 1, 2024v4
  2. Primary completion date: Feb 2028 to Nov 2028
    • Start date: Jan 2024 to Apr 2024
    • Study completion date: Mar 2028 to Dec 2028
    v3
  3. Start date: Aug 2023 to Jan 2024v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
AdventHealth
31 trials monitored
See 2 trials at risk
Depression
3,055 trials monitored
See 173 trials at risk
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypothesize that 4 weeks of a customized digital cognitive training program will lead to changes in brain connectivity, apathy severity, and cognitive control performance.
Trial Details
NCT Number NCT05877885
Lead Sponsor AdventHealth
Collaborators: National Institute of Mental Health (NIMH)
Conditions
(from sponsor)		 Major Depressive Disorder, Apathy
Related terms Lethargy, Major Depressive Disorder
Enrollment 84 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov