Clinical Trial

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

Recruiting
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Summary
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypothesize that 4 weeks of a customized digital cognitive training program will lead to changes in brain connectivity, apathy severity, and cognitive control performance.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2023-05-17; most recent amendment 2025-10-21.
Status change: Not Yet Recruiting → Recruiting 2025-10-21
Trial Details
NCT Number NCT05877885
Lead Sponsor AdventHealth
Collaborators: National Institute of Mental Health (NIMH)
Conditions Major Depressive Disorder, Apathy
Enrollment 84 participants
Start Date 2025-09-19
Primary Completion 2028-11-01 (estimated)
Study Completion 2028-12-01 (estimated)
Updated on ClinicalTrials.gov 2025-10-22