Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trigeminal nerve stimulation. This study requires participants to conduct daily at-home treatment sessions, attend three in-person study visits at the MUSC Department of Psychiatry and Behavioral Sciences, and complete electronic questionnaires over the 12-week trial, and again at the six-month timepoint. Participants in this trial may benefit directly with an improvement in sense of smell. However, participation may also help society more generally, as this study will provide new information about long COVID-related smell loss and its treatment.

NCT Number	NCT05855369
Lead Sponsor	Medical University of South Carolina Collaborators: National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions	Smell Dysfunction, Olfactory Disorder, Long COVID
Enrollment	145 participants
Start Date	2023-10-02
Primary Completion	2028-05-31 (estimated)
Study Completion	2028-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-02