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NCT05831085 · ClinicalTrials.gov record · last posted 2026-06-24

Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease

Name: Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease — clinical trial record (NCT05831085)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: DEFINE-DM

StatusRecruiting

PhaseNot applicable

SponsorDuk-Woo Park, MD

Started2024-06-14

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and three-vessel CAD (not involving left main).

Protocol amendment history 3 changes detected by DataLookout

2026-06-25

Trial sites expanded: 27 → 39 locations

2026-06-25

Primary completion pushed: 2027-06 → 2029-12-31

2026-06-25

Completion pushed: 2027-12 → 2029-12-31

Trial Details

NCT Number	NCT05831085
Lead Sponsor	Duk-Woo Park, MD Collaborators: CardioVascular Research Foundation, Korea
Conditions	Coronary Artery Stenosis
Enrollment	1,500 participants
Start Date	2024-06-14
Primary Completion	2029-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-24