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ctDNA in CRC Patients Undergoing Curative-intent Surgery for Liver Metastases

Study acronym: CLIMES
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 23, 2025 (before its estimated September 25, 2025 completion). Its status may not reflect the trial's current state.

Record History

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  1. Site details revised at 11 of 16 sitesv6
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Jan 15, 2024 to Jan 9, 2024
    • Site details revised at 16 of 16 sites
    v5
  3. Start date: Sep 25, 2023 to Jan 15, 2024v4
  4. Start date: Apr 25, 2023 to Sep 25, 2023v3 Show 4 more changesShow less
    • Primary endpoint revised
    • Eligibility criteria expanded, about 12 words
    • Secondary endpoints: 5 to 6
    • Study title shortened, about 8 words
  5. Start date: Mar 25, 2023 to Apr 25, 2023v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a prospective multicenter cohort study, was designed to explore the prognostic value of ctDNA as a biomarker of disease response and recurrence or death in patients undergoing curative-intent surgical resection of Colorectal cancer liver metastasis.
Trial Details
NCT Number NCT05787197
Lead Sponsor GERCOR - Multidisciplinary Oncology Cooperative Group
Conditions
(from sponsor)		 Metastatic Colorectal Cancer, Circulating Tumor DNA
Related terms Colorectal Neoplasms
Enrollment 232 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov