Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative

The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers. The main questions it aims to answer are: * Survival outcomes * Morbidity outcomes * Cost-effectiveness Participants will either undergo sentinel node biopsy followed by completion neck dissection if sentinel node is reported to be metastatic (SNB) or limited elective neck dissection where level IIb will be cleared only if level IIa is metastatic (limited END). The study will compare the outcomes in the two cohorts.

NCT Number	NCT05774483
Lead Sponsor	Tata Memorial Hospital Collaborators: Tata Memorial Centre
Conditions	Mouth Neoplasms, Oral Cancers, Oral Squamous Cell Carcinoma (OSCC), Oral Squamous Cell Carcinomas, Sentinel Lymph Node Biopsy, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node
Enrollment	508 participants
Start Date	2025-04-16
Primary Completion	2032-04 (estimated)
Study Completion	2034-04 (estimated)
Updated on ClinicalTrials.gov	2025-07-17