Clinical Trial

Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

Study acronym: SMART
Active, Not Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
Protocol Amendment History 3 changes
critical Enrollment closed, study ongoing 2026-08-13
notable Primary completion moved earlier: 2026-06-01 -> 2026-04-22 2026-08-13
minor Completion moved earlier: 2026-12-01 -> 2026-10-20 2026-08-13
Trial Details
NCT Number NCT05745987
Lead Sponsor McMaster University
Conditions Monkeypox
Enrollment 3,000 participants
Start Date 2024-09-17
Primary Completion 2026-04-22 (estimated)
Study Completion 2026-10-20 (estimated)
Updated on ClinicalTrials.gov 2026-08-12