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The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Study acronym: SCI
StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated September 2, 2025 (before its estimated August 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary and study completion dates: Mar 2024 to Aug 1, 2026
    • Start date: May 1, 2023 to Feb 1, 2023
    v3
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Mar 2023 to May 1, 2023
    • Site details revised
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position). The main questions it aims to answer are: 1. What are the various spinal sites and stimulation parameters that normalize and stabilize blood pressure during an orthostatic provocation (70 degrees tilt)? 2. Does training, i.e., exposure to repeated stimulation sessions, have an effect on blood pressure stability? Participants will undergo orthostatic tests (lying on a table that starts out flat, then tilts upward up to 70 degrees), with and without stimulation, and changes in their blood pressure will be evaluated.
Trial Details
NCT Number NCT05725499
Lead Sponsor Kessler Foundation
Conditions
(from sponsor)		 Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases, Cardiovascular Diseases, Trauma, Nervous System, Central Nervous System Diseases, Nervous System Diseases +1 more
Related terms Cardiovascular Diseases, Central Nervous System Diseases, Hypotension, Hypotension, Orthostatic, Nervous System Diseases, Spinal Cord Diseases, Spinal Cord Injuries, Trauma, Nervous System
Enrollment 5 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov