Clinical Trial

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Study acronym: SCI

Recruiting

Record status

This record was last updated September 2, 2025 (before its estimated August 1, 2026 completion). Its status may not reflect the trial's current state.

Summary

This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position). The main questions it aims to answer are: 1. What are the various spinal sites and stimulation parameters that normalize and stabilize blood pressure during an orthostatic provocation (70 degrees tilt)? 2. Does training, i.e., exposure to repeated stimulation sessions, have an effect on blood pressure stability? Participants will undergo orthostatic tests (lying on a table that starts out flat, then tilts upward up to 70 degrees), with and without stimulation, and changes in their blood pressure will be evaluated.

Protocol Amendment History 2 amendments

This ClinicalTrials.gov record has been amended 2 times since 2023-02-02; most recent amendment 2025-08-29.

Status change: Not Yet Recruiting → Recruiting 2023-05-08

Trial Details

NCT Number	NCT05725499
Lead Sponsor	Kessler Foundation
Conditions	Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases, Cardiovascular Diseases, Trauma, Nervous System, Central Nervous System Diseases, Nervous System Diseases +1 more
Enrollment	5 participants
Start Date	2023-02-01
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-08-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-02