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Shortened Course Adjuvant Radiotherapy Following TORS

StatusActive, Not Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 30, 2026 (before its estimated October 10, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion pushed from Apr 10, 2026 to Oct 10, 2026 Completion pushed from Apr 30, 2026 to Dec 30, 2026v8 Show 1 more changeShow less
    • Completion pushed from Apr 30, 2026 to Dec 30, 2026
  2. Trial status: Recruiting to Active, Not Recruiting Primary completion date: Dec 31, 2025 to Apr 10, 2026 · Site details revised at 3 of 3 sitesv7 Show 2 more changesShow less
    • Primary completion date: Dec 31, 2025 to Apr 10, 2026
    • Site details revised at 3 of 3 sites
  3. Secondary endpoints: 5 to 6 Site contacts updated at 1 of 3 sitesv6 Show 1 more changeShow less
    • Site contacts updated at 1 of 3 sites

    See this version in full on ClinicalTrials.gov ↗

  4. Re-verified, no change to tracked fieldsv5
  5. Phase: Not applicable to Phase 2 Primary completion date: Dec 31, 2024 to Dec 31, 2025 · Completion date: Apr 30, 2025 to Apr 30, 2026 · Interventions: adjuvant radiotherapy (Radiation) to Shortened Course Adjuvant Radiotherapy Following TORS (Radiation) · 4 morev4 Show 7 more changesShow less
    • Primary completion date: Dec 31, 2024 to Dec 31, 2025
    • Completion date: Apr 30, 2025 to Apr 30, 2026
    • Interventions: adjuvant radiotherapy (Radiation) to Shortened Course Adjuvant Radiotherapy Following TORS (Radiation)
    • Eligibility criteria shortened, about 7 words
    • Secondary endpoints revised (5)
    • Study description expanded, about 43 words
    • Study sites revised (3)

    See this version in full on ClinicalTrials.gov ↗

  6. 2 versions Re-verified since Jun 22, 2023, no change to tracked fieldsv2-v3
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a single-arm, phase II study to establish the safety of reducing radiation dose in selected HPV-Associated OPSCC patients receiving adjuvant radiation after TORS and neck dissection. This protocol also allows for sparing of the primary resection bed, in appropriate patients, as previously published by our group and found to be safe and effective.
Trial Details
NCT Number NCT05714657
Lead Sponsor Abramson Cancer Center at Penn Medicine
Conditions HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Enrollment 104 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov