Shortened Course Adjuvant Radiotherapy Following TORS

This is a single-arm, phase II study to establish the safety of reducing radiation dose in selected HPV-Associated OPSCC patients receiving adjuvant radiation after TORS and neck dissection. This protocol also allows for sparing of the primary resection bed, in appropriate patients, as previously published by our group and found to be safe and effective.

NCT Number	NCT05714657
Lead Sponsor	Abramson Cancer Center at Penn Medicine
Conditions	HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Enrollment	104 participants
Start Date	2023-01-30
Primary Completion	2026-10-10 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-30