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Minor3 versionsRe-verified since Jun 9, 2023, no change to tracked fieldsv40-v42
MinorStart date changed from estimate of Apr 6, 2023 to Mar 29, 2023v39
MinorStart date: Apr 4, 2023 to Apr 6, 2023v38
MinorStart date: Apr 3, 2023 to Apr 4, 2023v37
MinorStart date: Mar 31, 2023 to Apr 3, 2023v36
MinorStart date: Mar 30, 2023 to Mar 31, 2023v35
MinorStart date: Mar 28, 2023 to Mar 30, 2023v34
MinorStart date: Mar 27, 2023 to Mar 28, 2023v33
MinorStart date: Mar 24, 2023 to Mar 27, 2023v32
MinorStart date: Mar 22, 2023 to Mar 24, 2023v31
MinorStart date: Mar 21, 2023 to Mar 22, 2023v30
MinorStart date: Mar 20, 2023 to Mar 21, 2023v29
MinorStart date: Mar 19, 2023 to Mar 20, 2023v28
MinorStart date: Mar 16, 2023 to Mar 19, 2023v27
MinorStart date: Mar 15, 2023 to Mar 16, 2023v26
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
Substance use disorders (SUD) can be considered disorders in the way people process incentives, learn, and make decisions. To understand why some people develop SUD, researchers need to develop reliable tests that show how people think and learn. This natural history study seeks to develop a set of tasks that could then be used to test how people learn and make decisions.
Objective:
To develop and validate behavioral tasks that could be used in future studies.
Eligibility:
Healthy people aged 18-45 years from the Baltimore area. They must also be enrolled in the NIDA screening protocol.
Design:
Participants will perform different tasks. Most tasks require 1-4 study visits; some may require up to 12. Visits are 1-14 days apart. All visits will last about 1-7 hours.
Participants will perform tasks on a computer. As they work they may be given different stimuli:
Smells. Participants will sniff odors through a plastic tube or mask on their nose.
Flavors. Participants will wear a mouthpiece and small amounts of different flavored liquids will be placed in their mouth.
Pictures. Participants will look at different images.
Sounds. Participants will wear headphones and various sounds will be played for them.
Food. Participants may be asked to eat a meal before, during, or after a task. The researchers will provide the meal.
During each task, participants will wear sensors to monitor their heart rate, blood pressure, breathing, and other physical changes in their bodies.
Some participants will have a functional magnetic resonance imaging (fMRI) scan. They will lie on a table that slides into a cylinder. They will perform tasks on a computer screen during the fMRI.