Clinical Trial

Amplitude Titration to Improve ECT Clinical Outcomes

Recruiting
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Summary
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2). H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency
Protocol Amendment History 10 amendments
This ClinicalTrials.gov record has been amended 10 times since 2023-01-13; most recent amendment 2026-01-23.
Status change: Not Yet Recruiting → Recruiting 2023-12-15
Trial Details
NCT Number NCT05699226
Lead Sponsor University of New Mexico
Collaborators: National Institute of Mental Health (NIMH)
Conditions Depression, ECT, Cognitive Change
Enrollment 50 participants
Start Date 2023-09-14
Primary Completion 2027-01-01 (estimated)
Study Completion 2028-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-01-26